Joshua T Mattila Selected Research

Granuloma

10/2022	Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control.
1/2022	T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques.
1/2021	Retention of 64Cu-FLFLF, a Formyl Peptide Receptor 1-Specific PET Probe, Correlates with Macrophage and Neutrophil Abundance in Lung Granulomas from Cynomolgus Macaques.
12/2020	Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation.
1/2020	Spatial Organization and Recruitment of Non-Specific T Cells May Limit T Cell-Macrophage Interactions Within Mycobacterium tuberculosis Granulomas.
1/2020	IL-10 Impairs Local Immune Response in Lung Granulomas and Lymph Nodes during Early Mycobacterium tuberculosis Infection.
11/2019	Neutrophils express pro- and anti-inflammatory cytokines in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques.
11/2018	Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques.
1/2017	Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model.
1/2017	Positron Emission Tomography Imaging of Macaques with Tuberculosis Identifies Temporal Changes in Granuloma Glucose Metabolism and Integrin α4β1-Expressing Immune Cells.

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Joshua T Mattila Research Topics

Disease

17	Granuloma 10/2022 - 08/2012
12	Infections 01/2022 - 01/2007
12	Tuberculosis (Tuberculoses) 01/2020 - 03/2011
3	Fibrosis (Cirrhosis) 12/2020 - 01/2016
3	Inflammation (Inflammations) 01/2020 - 01/2017
1	Disease Progression 01/2019
1	Pulmonary Tuberculosis 01/2016
1	Infertility (Sterility) 01/2015
1	Pneumonia (Pneumonitis) 08/2014

Drug/Important Bio-Agent (IBA)

6	CytokinesIBA 01/2020 - 03/2011
5	VaccinesIBA 10/2022 - 10/2013
3	Interleukin-10 (Interleukin 10)IBA 01/2020 - 01/2015
3	AntigensIBA 11/2019 - 08/2012
3	Pharmaceutical PreparationsIBA 11/2018 - 01/2016
2	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 01/2017
2	EnzymesIBA 08/2015 - 07/2013
2	Proteins (Proteins, Gene)FDA Link 08/2015 - 07/2013
1	RNA (Ribonucleic Acid)IBA 10/2022
1	Transcription Factors (Transcription Factor)IBA 01/2022
1	MicronutrientsIBA 01/2021
1	Formyl Peptide Receptors (Formyl Peptide Receptor)IBA 01/2021
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2021
1	2-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA 12/2020
1	PeptidomimeticsIBA 01/2017
1	LigandsIBA 01/2017
1	IntegrinsIBA 01/2017
1	Integrin alpha4beta1 (VLA-4)IBA 01/2017
1	Hematoxylin (Haematoxylon)IBA 01/2016
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2016
1	trichrome stainIBA 01/2016
1	Eosine Yellowish-(YS) (Eosin)IBA 01/2016
1	Granzymes (Granzyme)IBA 08/2015
1	LipopolysaccharidesIBA 08/2015
1	PerforinIBA 08/2015
1	Indicators and Reagents (Reagents)IBA 03/2015
1	Anti-Bacterial Agents (Antibiotics)IBA 02/2015
1	Immunologic Factors (Immunomodulators)IBA 01/2015
1	Protein Isoforms (Isoforms)IBA 07/2013
1	ArginaseIBA 07/2013
1	Nitric Oxide Synthase (NO Synthase)IBA 07/2013
1	Interleukin-5 (Interleukin 5)IBA 06/2013
1	HLA-DR Antigens (HLA-DR)IBA 08/2012
1	AntibodiesIBA 08/2012
1	Immunoglobulin G (IgG)IBA 08/2012
1	Interleukin-4 (Interleukin 4)IBA 03/2011
1	Peptides (Polypeptides)IBA 01/2007
1	DefensinsIBA 01/2007
1	Muramidase (Lysozyme)IBA 01/2007

Therapy/Procedure

3	Therapeutics 01/2017 - 08/2014
1	Drug Therapy (Chemotherapy) 01/2016